The great music adventure in Show by Rock!! begins after Cyan decides to play her favorite rhythm game and suddenly gets sucked in, finding herself in a world called Midi City where music reigns supreme. She learns that anyone who delivers amazing and powerful music also has the ability to control the city. However, not all music is pure. An evil plan is set in motion to engulf the whole Midi City in darkness. Is it too late for Cyan to do something? Cyan Hijirikawa always regards herself as nothing but an ordinary girl living in a mediocre world. She has great talent and extreme guitar skills, but she also lacks the confidence to take the first step in realizing her dream to play in a band and be a music millionaire! Little did she know that an eminent power resides deep within herself—the power to defeat evil with her magical music! Join Cyan, Chuchu, Retoree and Moa in a world where music is everything.

It is the dark century and the people are suffering under the rule of the devil, Vandel, who is able to manipulate monsters. The Vandel Busters are a group of people who hunt these devils, and among them, the Zenon Squad is known to be the strongest busters on the continent. A young boy, Beet, dreams of joining the Zenon Squad. However, one day, as a result of Beet's fault, the Zenon squad was defeated by the devil, Beltose. The five dying busters sacrificed their life power into their five weapons, Saiga. After giving their weapons to Beet, they passed away. Years have passed since then and the young Vandel Buster, Beet, begins his adventure to carry out the Zenon Squad's will to put an end to the dark century.

A year after escaping Sword Art Online, Kazuto Kirigaya has been settling back into the real world. However, his peace is short-lived as a new incident occurs in a game called Gun Gale Online, where a player by the name of Death Gun appears to be killing people in the real world by shooting them in-game. Approached by officials to assist in investigating the murders, Kazuto assumes his persona of Kirito once again and logs into Gun Gale Online, intent on stopping the killer. Once inside, Kirito meets Sinon, a highly skilled sniper afflicted by a traumatic past. She is soon dragged in his chase after Death Gun, and together they enter the Bullet of Bullets, a tournament where their target is sure to appear. Uncertain of Death Gun's real powers, Kirito and Sinon race to stop him before he has the chance to claim another life. Not everything goes smoothly, however, as scars from the past impede their progress. In a high-stakes game where the next victim could easily be one of them, Kirito puts his life on the line in the virtual world once more.

A special episode bundled with the Nintendo DS game based on the series. Envious of seeing how Simon keeps his Lagann clean and neat, Kamina asks the mysterious Chitori to clean up his Gurren for him, unaware of her true intentions.