Sena is like any other shy kid starting high school; he's just trying to survive. Constantly bullied, he's accustomed to running away. Surviving high school is about to become a lot more difficult after Hiruma, captain of the school's American football team, witnesses Sena's incredible agility and speed during an escape from some bullies. Hiruma schemes to make Sena the running back of his school team, The Devil Bats, hoping that it will turn around the squad's fortunes from being the laughingstock of Japan's high school leagues, to title contender. To protect his precious star player from rivaling recruiters, he enlists Sena as "team secretary," giving him a visored helmet and the nickname "Eyeshield 21" to hide his identity. The Devilbats will look to make their way to the Christmas Bowl, an annual tournament attended by the best football teams in Japan, with "Eyeshield 21" leading the way. Will they be able to win the Christmas Bowl? Will Sena be able to transform from a timid, undersized freshman to an all-star player? Put on your pads and helmet to find out!

Koyomi Araragi is studying hard in preparation for his college entrance exams when he begins to notice something very strange: his reflection no longer appears in a mirror, a characteristic of a true vampire. Worried about the state of his body, he enlists the help of the human-like doll Yotsugi Ononoki and her master Yozuru Kagenui, an immortal oddity specialist. Quickly realizing what is wrong with him, Yozuru gives him two choices: either abstain from using the vampiric abilities he received from Shinobu Oshino, or lose his humanity forever. [Written by MAL Rewrite]

With Tenseiga having been broken by a spiteful Zero, Towa begins to infuse the heavenly healing sword with her limited amounts of demonic energy in order to revive Setsuna. Totosai and Jaken arrive at the scene, and Totosai states that he needs three whole days to mend Tenseiga. Unfortunately, by that time, Setsuna's vital essence will have been already sent to the Underworld, thus rendering the repaired Tenseiga powerless and that they have no other option but to rely on Towa's own demonic strength and will. While Towa struggles to utilize Tenseiga's heavenly abilities to try and save her twin's spiritual essence, Totosai retrieves the hilt of Setsuna's broken naginata and begins to restore it to create the blood bade she inherited from being one of Sesshomaru's half-demon daughters, the Yukari no Takichri. This greater infusion of a blend of pure demonic and mystical energy attracts a mass of demons both living and deceased. Moroha utilizes her somewhat stronger and more effective spiritual powers to purify a few dozen demons all at once with one single arrow alone, with backup from Kiara, but the two are largely outnumbered by their fellows. As the horde of demons' turn their attention to a concerned Sesshomaru and his unconscious twin daughters, the recently resurrected Setsuna awakes upon her name being said by her father, who fiercely holds her greatly advanced and upgraded naginata aloft, the Yukari no Tachikiri, and easily slays the demons, which Moroha and Kiara had not been able to do away with, in one single stroke. Sesshomaru then hands the broken Tenseiga to Totosai for its three day mending, and leaves with Jaken. Before leaving himself, Totosai warns Setsuna to never let herself be murdered again as the Tenseiga can only return sentient beings, human or demon, to life only once. While Towa remains unconscious from having drained herself of all her demonic energy to resurrect her twin sister, Totosai instructs Setsuna on how look for a mystical Kyuyokon root from the 214 year old Magnolia demon tree Bokusenoh to receive a proper demonic weapon for Towa, in place of the Kikujomonchi that she has been foolishly wielding since her return to the timeline of her birth.

In the heart of Italy, the Social Welfare Agency rescues young girls from hospital beds and gives them a second chance at life using the latest in cybernetic advancements. With their artificially enhanced bodies, the girls are brainwashed and trained as assassins to carry out the dirty work of the Italian Government. Despite all the modifications, they are still just children at heart, struggling for recognition from those they love, even knowing the love they feel is manufactured. This tragic tale unfolds as these girls grapple with their emotions in an agency that treats them as nothing but ruthless killers. [Written by MAL Rewrite]