The Seven Deadly Sins: Dragon's Judgement is an anime television series sequel to Wrath of the Gods. Where will the 3,000-year journey of Meliodas and Elizabeth lead? Who will emerge as the true enemy? The final arc begins in 2021.

After his high school graduation, Yuuki Wakura realizes it has been five years since his sister's disappearance during a "Mato disaster." Throughout Japan, mysterious entrances have opened to a dimension called "Mato"—a demonic metropolis filled with disastrous monsters known as the "Shuuki" that threaten the safety of humans. However, a new hope arose, as the discovery of a Mato fruit that grants supernatural abilities exclusively to women allowed them to fight against the Shuuki. Due to this, a new matriarchal government was formed, establishing a female organization called the Anti-Demon Corps, which caused men to fall to the bottom of society. When Yuuki suddenly finds himself in Mato, he is unable to escape on his own. But just as he anticipates a gruesome end by the Shuuki, a girl in a militia outfit appears and protects him. As the chief of the Seventh Unit of the Anti-Demon Corps, Kyouka Uzen is ambitious yet devalued by her own peers due to her power being deemed unusual. Now in a life-or-death situation, Kyouka takes the opportunity to find out the true potential of her superpower by using Yuuki: in order to defeat the Shuuki, he has to become her slave.

Individuals who can materialize weapons from their soul are called "Blazers," and they attend Kouryou Academy High School in order to harness their abilities. Each student is required to partner with another, in the hopes that one day, the pair can attain the power of Absolute Duo. Tooru Kokonoe hopes to attend this academy in order to gain power after his sister and friends were slain by a mysterious man. However, at the opening ceremony, he is forced to duel against the person sitting next to him, with the loser being expelled. As Tooru prepares to give the match his all, it is not a weapon that manifests from his soul, but a shield, an irregularity which catches the attention of a foreign student named Julie Sigtuna. [Written by MAL Rewrite]

High schooler Ganta Nakami has trouble falling asleep most nights. As a result, he is irritable at school, always searching for an opportunity to find a secluded place to doze off. On the other hand, Isaki Magari is a free spirit who is well liked by her friends, but no one is aware of her sleep disorder. She makes use of the school's abandoned astronomy club observatory as her secret sleeping bunker when she needs to get some shut-eye. As fate would have it, Nakami finds Magari napping in the observatory. When Magari discovers that she and Nakami have something in common, she offers to share her secret sleeping spot with her fellow insomniac. As the two find warmth in each other's company, the struggles they face start to become easier to confront.