Tokiro Ehara, an idealistic geeky professor, begins teaching at an exclusive high school for girls, with hopes of meeting young innocent minds in their most fragile state. Unfortunately, on his way to work, he meets 18-year-old Miyako and finds out that she is one wild student that needs to be taught how a prim and proper teenager should behave. He starts to believe that he is just the right person to teach her. Miyako, however, has other plans, and she's not above using her seductive wiles to lure him into submission.

Set 10 years after Mahou Shoujo Lyrical Nanoha A's, Nanoha, Fate, Hayate and the rest of the crew are now working full time in the Time-Space Administration Bureau. Nanoha is a combat instructor, Fate is a special investigator, and Hayate is a commanding officer. They must unite once again to save the dimensions. Introducing new characters as well: Subaru, Teana, Caro and Erio. Stand by. Ready. Set up!

In the peaceful theocracy of Simulicram, everyone is born female. At age 17, each maiden undergoes a special ceremony where she chooses her sex. However, only Pairs of maiden priestesses can synchronize with the ancient flying ships known as Simoun needed to defend Simulicram. These Pairs refrain from undergoing the ceremony as long as they wish to keep piloting their Simoun. Aer is recruited to be a Simoun pilot after a terrifying attack by an enemy nation decimates the squadron known as Chor Tempest. To earn her wings she needs to find her way into the heart of Neviril, Regina of Chor Tempest. But Neviril's heart still belongs to her previous Pair, lost in the battle when she attempted a forbidden Simoun maneuver. (Source: Media Blasters)

The anime series is set in the future when humanity migrated to the Moon due to Earth's climate change. It will incorporate original elements unique to the anime, such as human drama about survival, and will feature a diverse field that blurs countries and eras such as Shibuya, the Edo-period era, and London.