The Daichis are a family in danger of tearing itself apart. Dissatisfied and money obsessed mom Seiko has served wimpy and otaku dad Mamoru with divorce papers. Daughter Nozomi who has always been saddled with all the housework, feels pained that everyone is using her. The youngest albeit most foul mouthed, Dai is forced to watch all this as everything is going to pieces. However when the Galaxy Federation recruits the Daichis to combat alien threats to the wellbeing of the Earth, it will be a chance for the family to save the world and maybe themselves.

The One Year War comes to a close, as the Zeon forces now retreat back into space. Amuro learns much more of his Newtype abilities and tries to use them the best way he can. He's pushed to his limit as he encounters the infamous Char Aznable once again. He also falls in love with a mysterious woman named Lalah Sune, who knows the full potential of the Newtype abilities. The greatest battle is about to begin, as many loved ones fall to the power of war. Can the Earth Federation defeat the Principality of Zeon? Or will they fail? Can Char prove that he's the better Newtype than Amuro? They all will be answered now...

In the distant future, humanity is hurtling down a path of ruin. Global environmental destruction caused by chemical contamination, radioactive fallout, and UV rays coming through the patchy ozone layer has lead to deterioration of the human genome.

As the War continues, Amuro and the White Base crew must make their way toward the Earth Federation Headquarters, Jaburo. On their way they meet several new enemies and face off against impossible odds. They fight in Operation Odessa to relieve the Earth from the clutches of the Zeon forces. Lives are lost, new friendships are made, and discoveries at every corner. Amuro soon learns that he possesses the powers of the mysterious Newtypes.